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Raveendra Reddy, P.
- Direct and Derivative Spectrophotometric Determination of Chromium(VI) in Microgram Quantities Using 5-Bromo Salicylaldehyde Isonocotinoyl Hydrazone (5-BrSAINH)
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Authors
Affiliations
1 Department of Chemistry, Sri Krishnadevaraya University, Anantapur, 515003 (A.P), IN
1 Department of Chemistry, Sri Krishnadevaraya University, Anantapur, 515003 (A.P), IN
Source
Asian Journal of Research in Chemistry, Vol 6, No 7 (2013), Pagination: 667-670Abstract
A highly sensitive and selective spectrophotometric method was developed for the determination of trace amount of chromium (VI) in aqueous DMF medium. The chromate ion forms a light brown colored complex with 5-Bromo salicylaldehyde isonocotinoyl hydrazone (5-BrSAINH) in an acidic buffer of pH 6.0. The complex has an absorbance maximum at 430nm, was stable for more than 72 hours. Beer's law is obeyed in the range 0.16 - 3.90 μgml-1. The molar absorptivity and sandell's sensitivity of the colored solution were found to be 2.0 x 104 L.mol-1cm-1 and 2.6 X 10-3 μgcm-2, respectively. The light brown colored complex has 1:1 (Chromium (VI) - 5BrSAINH) Stoichiometry. The stability constant of the complex was determined as 1.40 X 106 by Job's method. The effect of foreign ions on the determination was studied. A sensitive and selective first and second order derivative spectrophotometry has also been proposed for the determination of Cr (VI). The interference of various cations and anions were studied. The developed methods were successfully employed in the determination of Cr (VI) in soil and standard steel samples.Keywords
Spectrophotometry, 5-BrSAINH, Determination of Chromium (VI), Soil Samples, Standard Steel Samples
References
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- Sreevani I Raveendra Reddy P, Krishna Reddy V , A Rapid and Simple Spectrophotometric Determination of traces of Chromium (VI) in Waste Water Samples and in Soil samples by using 2- Hydroxy, 3-Methoxy Benzaldehyde Thiosemicarbazone (HMBATSC), IOSR Journal of Applied Physics 3(1) (Jan. - Feb. 2013), PP40:45.
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- Visible Extractive Spectrophotometric Estimation of Sofosbuvir in Bulk and in Pharmaceutical Formulations
Abstract Views :189 |
PDF Views:0
Authors
Affiliations
1 Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, IN
2 Analytical Department, Vishnu Chemicals Limited, Jeedimetla, Hyderabad, IN
3 Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy Mount Pleasant, Hyderabad-500 034., IN
1 Department of Chemistry, Sri Krishnadevaraya University, Anantapur-515003, IN
2 Analytical Department, Vishnu Chemicals Limited, Jeedimetla, Hyderabad, IN
3 Department of Pharmaceutical Chemistry, Sultan-Ul-Uloom College of Pharmacy Mount Pleasant, Hyderabad-500 034., IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 4 (2019), Pagination: 1517-1520Abstract
Two simple, accurate, rapid and sensitive methods (A and B) have been developed for the estimation of Sofosbuvir in pharmaceutical dosage form. The Method A is based on reaction of Sofosbuvir with ferric chloride and 1,10-phenanthroline to form a blood red colored chromogen. The Method B is based on reaction of Sofosbuvir with ferric chloride and 2,2'- bipyridyl to form a red colored ferroin complex measured at 520 nm, against reagent blank. These Methods exhibit maximum absorption at 510 nm and 520 nm respectively and obey the Beer’s law in the concentration range of 10-140 μg/mL and. 5-50 μg /mL respectively. The Methods have been statistically evaluated and were found to be precise and accurate. The proposed methods are economical and sensitive for the estimation of Sofosbuvir in bulk drug and in its formulations.Keywords
UV-Visible Spectrophotometry, Sofosbuvir, Ferric Chloride, 1, 10-Phenanthroline, and 2, 2’ Bipyridyl.References
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